Gastric Bypass May Prevent Cancer
Monday, June 23rd, 2008My local newspaper, The East Valley Tribune, had an article yesterday headlined, “Study says gastric bypass surgery reduces cancer rates.” Google found me an online version of the story from another source. I assume the Canadian researchers issued a news release.
Researchers at McGill University followed 1,035 gastric bypass patients over five years or more, with 5,746 obese people serving as controls. “Controls” means they did not have the surgery but were otherwise similar to the surgical group. The bypass patients lost 67% of their excess weight, which is considered successful surgery.
Breast and colon cancers were reduced by 85% and 70%, respectively. Obesity is associated with increased risk of breast and colon cancer, so some reduction would make sense intuitively. You might guess that loss of excess weight by any method would reduce risk of developing breast or colon cancer. You may or may not be right. But cancer death reduction has been ”proven” for weight loss only via bariatric surgery, not other weight-loss methods. Utah surgeons reported 60% lower risk of death from cancer after bariartric surgery (see reference below).
The Canadian researchers reported that skin cancer was reduced by 60%, which is surprising. Obesity is not associated with skin cancer. They also report a 50% reduction in non-Hodgkins lymphoma and 70% reduction in pancreatic cancer. Those cancers have not consistently been associated with obesity in the past. Furthermore, pancreatic cancer and non-Hodgkins lympoma are not common, and you wouldn’t expect many cases, if any, to occur in such a small sample size (6781 people). I suspect the observed reductions in skin cancer, pancreatic cancer, and lymphoma are not valid and reproducible. But who knows? We need more details of the study, including the statistical analysis.
My point in bringing up this subject is to caution you that these results are preliminary. I hope they are real, meaning reproducible and reliable. Prior research from Utah tends to confirm the essential finding: bariatric surgery significantly reduces cancer rates. The Canadians undoubtedly have submitted their report to one or more medical scientific journals for publication at a future date. A major part of the publication process involves “peer review.” The manuscript for publication will be reviewed by independent experts in the field who are in a position to judge whether the study was well-designed, valid, and reliable. If not, the findings will not gain credibility among the medical/scientific community and will be ignored. We may not see publication of the study details in a peer-reviewed journal for over a year.
Much hangs in the balance here: increased insurance coverage for the surgery, the volume of future gastric bypass operations, and people’s lives. The odds of dying from a surgical complication are about one in 200.
Steve Parker, M.D., author of The Advanced Mediterranean Diet
Reference: Adams, Ted, et al. Long-Term Mortality after Gastric Bypass Surgery. New England Journal of Medicine, 357 (2007): 753-761.



